Geldanamycin

Cat. No: AF3044






Package Size

500 mg

Price

$ 1150

Availability

In stock

Technical Data

Chemical Name
9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate


Biological Description
Geldanamycin is a benzoquinone ansamycin antibiotic that selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity.Geldanamycin induces the degradation of proteins that are mutated in tumor cells such as v-Src, Bcr-Abl and p53 preferentially over their normal cellular counterparts. This effect is mediated via HSP90.


Molecular Weight
560.6 daltons 


Molecular Formula

C29H40N2O9

 


Solubility
Soluble in DMSO (10 mg/ml) 


Purity
>98% 


Storage instructions
Up to one week at 4°C or six months at -20°C. 


CAS No.
30562-34-6 

References

Koga, F., et al. 2007. Cell Cycle. 6: 1393-1402.